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Functional Neurology: Akkermansia Muciniphila for Metabolic Syndrome

According to scientists, our gut microbiome may be associated with health issues like metabolic syndrome, including heart disease, stroke, and diabetes. Scientists demonstrated that Akkermansia muciniphila, a culture of bacteria naturally found in the gastrointestinal (GI) tract of healthy people, may be associated with weight loss in humans. While diet and lifestyle modifications are recommended to help regulate metabolic syndrome and its associated health issues, recent research studies determined that using "beneficial" gut bacteria, such as A. muciniphila, may regulate excess weight and obesity.

How A. Muciniphila Can Help Improve Metabolic Syndrome

A research study in the Louvain Drug Research Institute of the University of Louvain and the Cliniques Universitaires Saint-Luc found that A. muciniphila supplements reduced the risk of developing metabolic syndrome and other health issues like heart disease, stroke, and diabetes in people with excess weight and obesity. Scientists are currently preparing larger-scale research studies to market A. muciniphila as a food supplement within the next few years.  Research studies demonstrated that A. muciniphila supplements are a safe and effective intervention for people with excess weight and obesity.

Other research studies demonstrated the effects of Akkermansia muciniphila in overall health and wellness. In 2007, scientists demonstrated that A. muciniphila can improve the development of obesity and type 2 diabetes in a group of mice. Scientists also found that a pasteurized form of the beneficial gut bacteria improved risk factors, such as insulin resistance. Further research studies are required to determine if supplements of the pasteurized A. muciniphila have the same effects in humans. Scientists also need to evaluate the metabolic effects of A. muciniphila supplements in humans.

A randomized, double-blind, placebo-controlled pilot research study included 40 participants with excess weight or obesity with insulin resistance. The participants were separated into three different groups which were given daily supplements of either placebo, live A. muciniphila, or pasteurized A. muciniphila, throughout three months. The participants were asked to follow their regular diets and lifestyles without changing what they ate and exercise or physical activity levels. The results of the research study concluded what other research studies had previously demonstrated in the groups of mice.

According to the research studies, pasteurized A. muciniphila supplements helped improve essential metabolic parameters as well as helped reduce inflammatory markers in the participants. Pasteurized A. muciniphila also considerably helped improve approximately 30 percent of the participant's insulin sensitivity index compared with the placebo group, however, the live A. muciniphila supplements helped improve insulin resistance score in the participants. The pasteurized A. muciniphila supplements were also associated with a small decrease in body weight and body fat mass in the participants.

Recent research studies also found that A. muciniphila supplements can help reduce plasma cholesterol levels in mice as well as prevent the development of atherosclerosis in other animal models. Results from current research studies on humans demonstrated that pasteurized A. muciniphila considerably reduced approximately 8.68 percent total cholesterol levels compared with the placebo group while low-density lipoprotein (LDL) or "bad" cholesterol decreased about 7.53 percent and triglycerides decreased about 15.71 percent, however, these results were not ultimately considered significant.

Compared with the positive effects of A. muciniphila supplements on essential metabolic parameters, the participants in the placebo group had an increased risk of developing insulin resistance and hypercholesterolemia, among other health issues associated with metabolic syndrome as well as heart disease, stroke, and diabetes. Moreover, the research studies demonstrated that taking Akkermansia muciniphila supplements had no noticeable changes in the participant's gut microbiome. The results show that pasteurized or live A muciniphila supplements did not affect the overall gut microbiome.

Scientists currently understand that recent research studies did have several limitations, including that these were ultimately small-scale trials which mean that the results didn't offer definitive conclusions associated with essential metabolic parameters in the participants. Scientists also determined that the results of the research studies didn't find considerable changes in visceral adiposity and BMI in the participants. However, scientists concluded that the outcome measures did show the feasibility of administering A. muciniphila to humans with metabolic syndrome and its associated health issues.



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According to scientists, our gut microbiome may be associated with health issues like metabolic syndrome, including heart disease, stroke, and diabetes. Approximately 50 million adults in the United States have metabolic syndrome. Fortunately, scientists demonstrated that Akkermansia muciniphila, a culture of bacteria naturally found in the gastrointestinal (GI) tract of healthy people, may be associated with weight loss in humans. Excess weight and obesity can ultimately lead to metabolic syndrome and other health issues like heart disease, stroke, and diabetes. While diet and lifestyle modifications are recommended to help regulate metabolic syndrome and its associated health issues, recent research studies determined that using "beneficial" gut bacteria, such as A. muciniphila, may regulate excess weight and obesity as well as improve essential metabolic parameters. Dr. Alex Jimenez D.C., C.C.S.T. Insight

According to scientists, our gut microbiome may be associated with health issues like metabolic syndrome, including heart disease, stroke, and diabetes. Scientists demonstrated that Akkermansia muciniphila, a culture of bacteria naturally found in the gastrointestinal (GI) tract of healthy people, may be associated with weight loss in humans. While diet and lifestyle modifications are recommended to help regulate metabolic syndrome and its associated health issues, recent research studies determined that using "beneficial" gut bacteria, such as A. muciniphila, may regulate excess weight and obesity.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900

Curated by Dr. Alex Jimenez

References:
  1. GEN Staff. “Bacterial Supplement May Cut Risk of Heart Disease in Obese People.” GEN, GEN Media, 3 July 2019, www.genengnews.com/news/bacterial-supplement-could-cut-risk-of-cardiovascular-disease-in-overweight-people/.
  2. Cani, Patrice D., et al. “Akkermansia Muciniphila Helps Improve Features of Metabolic Syndrome in Overweight and Obese Subjects.” Gut Microbiota for Health, 16 July 2019, www.gutmicrobiotaforhealth.com/en/akkermansia-muciniphila-helps-improve-features-of-metabolic-syndrome-in-overweight-and-obese-subjects/.
  3. Depommier, Clara, et al. “Supplementation with Akkermansia Muciniphila in Overweight and Obese Human Volunteers: a Proof-of-Concept Exploratory Study.” Nature Medicine, U.S. National Library of Medicine, July 2019, www.ncbi.nlm.nih.gov/pubmed/31263284.

Additional Topic Discussion: Chronic Pain

Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient's mobility and it can reduce flexibility, strength, and endurance.





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The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request. We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to contact us. Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN* email: coach@elpasofunctionalmedicine.com phone: 915-850-0900 Licensed in: Texas & New Mexico*