Is It Really Autoimmunity? | El Paso, TX. | Part II Skip to main content

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Is It Really Autoimmunity? | El Paso, TX. | Part II

Autoimmunity: One of the most common things is to leave the doctor’s office with a diagnosis of an autoimmune disease and no nutritional or lifestyle changing insight. Autoimmune diseases are related to inflammation. Keeping  the inflammation down is the goal with autoimmune attacks. The foods you eat make a huge difference in the frequency and severity of flare-ups. Steady dietary changes can help you reach your optimal self.

Is Autoimmune Disease A Result Of The Collective Perturbations Of The Exposome & Its Impact On The Immunometabolic System?


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autoimmunity el paso tx.

The Exposome

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Exposome Influence On SLE

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The Ecology Of The Exposome

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Exposome & The Alteration Of “Self”

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The Exposome Connections To Autoimmune Diseases Converting Self Into Non‐Self

  • Immunometabolic dysfunctions through diet and lifestyle imbalances
  • Gut Ecology and the Microbiome
  • ViralorBacterialInfections
  • Hormones
  • Drugs
  • Chemicals
  • IonizingRadiation
  • PsychologicalStress
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autoimmunity el paso tx.

Cross‐Talk Among The Endocrine, Immune & Metabolic Systems

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Multi‐Organ Network Biology

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In Autoimmunity, Warburg Metabolism Is Increased Through Increased Activity Of GAPDH

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Blocking Immune Cell Glycolysis & “Starving” Its Function

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Ketogenic Diet’s Potential Impact On GAPDH Immunometabolic Regulation

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Origin Of IL‐17 Producing Th17 Cells

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What Is The Relationship Of The Gut Microbiome To Autoimmune Disease?

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autoimmunity el paso tx.



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High Fiber Influences On Diabetes In Animal Model

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80% Of Patients With Autoimmune Disease Are Female

Why?

Estrogen & Autoimmunity

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  • The greatest association with autoimmune diseases is the female gender
  • 17‐beta estradiol seems to play a role in activating T cells in autoimmune disease
  • T cells have ER‐alpha receptors that are activated by 17‐beta estradiol resulting in the production of inflammatory cytokines
  • Blocking ER‐alpha receptors may have a beneficial effect on autoimmune activation

Eleanor Rogan, PhD IFM Linus Pauling Award Winner

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www.JeffreyBland.com

 

Estrogen & Androgen Metabolism

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4‐Hydroxyestrogens & DNA reactivity

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Indole‐3‐Carbinol (I3C) Inhibition Of ER‐Alpha

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Relationship Of Hepatic Drug Detoxification To Anti‐Nuclear Antibody Development

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Making Friends With Ourselves: Clinical Implications

  • Reduce exposure to agents that activate immunometabolic dysfunction through the exposome
  • – Dietary
  • – Infection
  • – Parasites
  • – Xenobiotics
  • – Hormone
  • – Allergy
  • – Specific medications
  • – Dysbiosis
  • Reduce exposure to DNA damage (radiation, chemicals)
  • Support hepatic detoxification
  • Implement gastrointestinal restoration program
  • Reduce metabolic inflammation and endotoxin
  • Reduce psychological stress factors that activate HPA axis

Jeffrey Bland, PhD
Chairman Emeritus & Member, Board of Directors The Institute for Functional Medicine

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